Genetics of COPD

Homozygosity for the Z allele of the alpha1-antitrypsin gene is the primarily known genetic risk factor for COPD. Heterozygotes for the Z allele may be at higher risk as well. Other mutations influencing alpha1-antitrypsin structure or gene expression regulation have been considered as risk factors. COPD isn't always carried down in generations. Things you're exposed to, such as cigarette smoke or chemical fumes, are usually the reason. However, genes can sometimes have a role in illness.

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